2. Neurological Disease

Neurological Disease

Neurological Disease

Related Products

PDF 88.0 MB

A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P1498
    Substance P, Free Acid 71977-09-8 98.07%
    Substance P, Free Acid is a native substance P analog, but shows no biological activity of substance P.
    Substance P, Free Acid
  • HY-P1501
    δ-Sleep Inducing Peptide 62568-57-4 99.95%
    δ-Sleep Inducing Peptide is a neuropeptide, with antioxidant and anxiolytic properties.
    δ-Sleep Inducing Peptide
  • HY-P1506
    [Nle11]-Substance P 57462-42-7 98%
    [Nle11]-Substance P is a substance P analog that avoids methionine oxidation problems.
    [Nle11]-Substance P
  • HY-P1510
    β-Amyloid (1-11) 190436-05-6 98%
    β-Amyloid (1-11) is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease.
    β-Amyloid (1-11)
  • HY-P1511
    PACAP-Related Peptide (PRP), human 98%
    PACAP-Related Peptide (PRP), human is a 29 amino-acid region of the PACAP precursor protein.
    PACAP-Related Peptide (PRP), human
  • HY-P1521
    β-Amyloid (15-21) 365537-52-6 98%
    β-amyloid (15-21) is a fragment of Amyloid-β peptide, maybe used in the research of neurological disease.
    β-Amyloid (15-21)
  • HY-P1524
    β-Amyloid (1-14),mouse,rat 98%
    β-Amyloid (1-14),mouse,rat is a 1 to 14 fragment of Amyloid-β peptide.
    β-Amyloid (1-14),mouse,rat
  • HY-P1543
    Exendin-3 130357-25-4 98.31%
    Exendin-3 is a biologically active peptides isolated from venoms of the Gila monster lizards, Heloderma horridurn.
    Exendin-3
  • HY-P1544
    Cerebellin 94071-26-8 98%
    Cerebellin is a neuromodulatory hexadecapeptide that serves as a marker for Purkinje cell maturation. Cerebellin stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway. Cerebellin reduces insulin secretion from pancreatic islets under high-glucose conditions. Cerebellin also regulates synaptic structure formation and controls catecholamine secretion in peripheral tissues. Cerebellin can be used in neurological research.
    Cerebellin
  • HY-P1545
    ACTH (1-17) 7266-47-9 98%
    ACTH (1-17), an adrenocorticotropin analogue, is a potent human melanocortin 1 (MC1) receptor agonist with a Ki of 0.21 nM.
    ACTH (1-17)
  • HY-P1557
    Somatostatin-28 (1-12) 81286-16-0 98%
    Somatostatin-28 (1-12) is a somatostatin fragment that is monitored in brain tissue to track processing of somatostatin.
    Somatostatin-28 (1-12)
  • HY-P1567
    β-Amyloid (10-35), amide 181427-66-7 98%
    β-Amyloid (10-35), amide is composed of 26 aa (10-35 residues of the Aβ peptide) and is the primary component of the amyloid plaques of Alzheimer’s disease.
    β-Amyloid (10-35), amide
  • HY-P1588
    Scyliorhinin II 112748-19-3 98%
    Scyliorhinin II is a selective neurokinin-3 receptor agonist, with a Ki of 2.5 nM for neurokinin-3 receptor in rat cerebral cortex.
    Scyliorhinin II
  • HY-P1594
    Dynorphin A (1-10) 79994-24-4 98%
    Dynorphin A (1-10) an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor. Dynorphin A (1-10) also blocks NMDA-activated current with an IC50 of 42.0 μM.
    Dynorphin A (1-10)
  • HY-P1599
    Valorphin 144313-54-2 98%
    Valorphin is an endogenous hemoglobin β-chain (33-39) fragment with opioid analgesic activity, binds to rat mu-opioid receptor, with an IC50 of 14 nM; Valorphin also shows anti-tumor activity.
    Valorphin
  • HY-P1617
    LY 190388 105496-35-3 98%
    LY 190388 is a penicillamine-containing enkefa peptide analog with μ receptor agonist activity. LY 190388 showed analgesic effect in inhibiting the writhing response in mice after intracerebroventricular administration. The analgesic effect of LY 190388 is not caused by its δ receptor agonist action, but by its μ receptor agonist activity. When LY 190388 is used together with the δ receptor antagonist ICI 174864, an additive analgesic effect is produced.
    LY 190388
  • HY-P1618
    LY-281217 105027-75-6 98%
    LY-281217 is a potent mu-opioid agonist with analgesic effects.
    LY-281217
  • HY-P1625
    Daeatal 103614-28-4 98%
    Daeatal (Dynorphin A ethylamide (1-9)) is an ethylamine-modified dynorphin fragment that can be used in the study of analgesia, addiction, depression, etc. Dynorphin A is an endogenous opioid peptide involved in inhibitory neurotransmission in the central nervous system (CNS). Dynorphin A is a highy potent kappa opioid receptor (KOR) agonist, and is also an agonist for other opioid receptors, such as mu (MOR) and delta (DOR). Dynorphin A can induce neuronal death, and can be used in the research of neurological disease.
    Daeatal
  • HY-P1681
    GpTx-1 1661050-12-9 98%
    GpTx-1 is a peptide-based NaV1.7 sodium channel antagonist isolated from the venom of the Chilean spider Grammostola porter. GpTx-1 demonstrates potent inhibitory activity against the NaV1.7 channel with an IC50 value of 10 nM, while exhibiting excellent selectivity for NaV1.4 (IC50 = 0.301 μM) and NaV1.5 (IC50 = 4.20 μM), showing >20-fold and >950-fold selectivity respectively.
    GpTx-1
  • HY-P1691
    Leucopyrokinin 104052-00-8 98%
    Leucopyrokinin is a myotropic neuropeptide, which accelerates pupariation via central innervation, promotes tanning age dependently. Leucopyrokinin shapes the puparium by contracting and shrinking the integument.
    Leucopyrokinin
Cat. No. Product Name / Synonyms Application Reactivity